Prof. Min Chang's research focuses on synthetic organic chemistry and medicinal chemistry, with particular interests in skeletal editing, nitrogen-containing heterocycle synthesis, natural-product-inspired drug discovery, and targeted small-molecule therapeutics. He received systematic training in asymmetric organocatalysis, complex nitrogenous scaffold construction, and natural product total synthesis. During his Ph.D. studies in Prof. Daniel Seidel's laboratory, he developed new asymmetric catalytic strategies for Povarov and aza-Diels–Alder reactions, enabling efficient access to polycyclic nitrogen-containing frameworks and the first  total synthesis of Mariline A. His postdoctoral work further expanded into asymmetric haloazidation and concise terpene natural product synthesis, including work published in Nature Chemistry. Before beginning his independent career, Dr. Min worked at Incyte, where he contributed to KRAS-targeted anticancer drug discovery,  resulting in multiple U.S. patents and patent applications.Since establishing his independent research group, Dr. Min has focused on developing new reaction strategies for precise molecular editing and medicinal chemistry applications. His group integrates organic synthesis, skeletal editing, natural product chemistry, and drug discovery to create new tools for lead compound discovery, scaffold hopping, and structure–activity relationship studies.

Education Background and Research Experience

• Aug. 2022 – Present: Professor, School of Pharmaceutical Sciences, Wuhan University

• Sep. 2019 – Jul. 2022: Senior Scientist, Discovery Chemistry, Incyte Corporation

• Nov. 2016 – Sep. 2019: Postdoctoral Fellow , Department of Chemistry, Stanford University (Supervisor: Prof. Barry Trost)

• Sep. 2011 – Oct. 2016: PhD, Department of Chemistry and Chemical Biology, Rutgers University–New Brunswick (Supervisor: Prof. Daniel Seidel)

• Sep. 2009 – Jul. 2011: M.S., School of Pharmaceutical Sciences, Wuhan University (Supervisor: Prof. Haibing Zhou)

• Sep. 2005 – Jul. 2009: B.S., School of Pharmaceutical Sciences, Wuhan University

Awards

• 2015, Thomas Reid Fellow Award

• 2014，Van Dyke Research Award

• 2013，Krishnamurthy Award for outstanding paper or thesis in synthetic organic chemistry

• 2013，Poster Prize, ACS Pharmaceutical Roundtable Green Chemistry Symposium

• 2012，Wuhan University Award for Research Excellence

• 2011，Wuhan University Graduate Student Fellowship

Professional Membership

• Youth Member, Medicinal Chemistry Committee, Chinese Pharmaceutical Association

Publications

Independent Research at Wuhan University

23. Yun Luo, Lin Zhou*, Xiaotian Qi and Chang Min*. Divergent Skeletal Editing of Pyridinium Salts to Azepinones and Pyrrolidinones via Formal Carbonyl Insertion. J. Am. Chem. Soc. 2026, 148, 19148-19160.

22. Zhao Li and Chang Min*.  Aminophthalimide as a Protected Nitrogen Source for N-Insertion to Indenones.  Org. Lett. 2026, 28, 15, 4772–4776

21.  Yun Luo, Jing Dai*, Yongchang Wei* and Chang Min* Skeletal Editing from pyridine to Aniline via C-Insertion and N-Isomerization. ChemistryEurope. 2025, e202500410.

20. Huiguang Yu, Lili Xu, Luyao Li and Chang Min*. Scaffold Hopping of α,β‑Unsaturated Ketones via Divergent Alkyl Amine Insertion. J. Am. Chem. Soc. 2025, 147, 26584-26594. 

19. Lilan Xin, Chao Wang, Yan Cheng, Hongli Wang, Xinyi Guo, Xiaofei Deng, Xiangping Deng, Baohua Xie, Hankun Hu, Chang Min, Chune Dong,* and Hai-Bing Zhou*. Discovery of Novel ERα and Aromatase Dual-Targeting PROTAC Degraders to Overcome Endocrine-Resistant Breast Cancer.  J. Med. Chem. 2024, 67, 8913−8931.

18. Xiangping Deng, Xiaofei Deng, Wentao Ning, Lilan Xin, Qiuzi Li, Zhiye Hu, Baohua Xie, Kaiwei Liang, Chang Min, Chune Dong*, Jian Huang*, and Hai-Bing Zhou*. Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. J. Med. Chem. 2023, 66, 11094−11117.

Before Wuhan University

17. Moises A. Romero Reyes, Subhradeep Dutta, Minami Odagi, Chang Min, Daniel Seidel. Catalytic Enantioselective Synthesis of 2‑Pyrazolines via One‑Pot Condensation/6π‑Electrocyclization: 3,5‑Bis(Pentafluorosulfanyl)‑Phenylthioureas as Powerful Hydrogen Bond Donors. Chem. Sci. 2024, 15, 15456–15462.

16.  Barry M. Trost*, Zhiwei Jiao, Ying Liu, Chang Min, Chao‑I. Joey Hung. Palladium‑Catalyzed Enantioselective Cycloadditions of Aliphatic 1,4‑Dipoles: Access to Chiral Cyclohexanes and Spiro[2.4]heptanes. J. Am. Chem. Soc. 2020, 142, 18628−18636.

15.  Barry M. Trost*, Chang Min. Total Synthesis of Terpenes via Palladium‑catalysed Cyclization Strategy. Nat. Chem. 2020, 12, 568.

14. Barry M. Trost*, Anand H. Shinde, Youliang Wang, Zhijun Zuo, Chang Min. Palladium‑catalyzed Regio‑, Enantio‑, and Diastereoselective Asymmetric [3 + 2] Cycloaddition Reactions: Synthesis of Chiral Cyclopentyl Phosphonates. ACS Catal. 2020, 10, 1969.

13. Minami Odagi, Hiroshi Araki, Chang Min, Eri Yamamoto, Thomas J. Emge, Masahiro Yamanaka, Daniel Seidel*. Insights into the Structure and Function of a Chiral Conjugate‑Base‑Stabilized Brønsted Acid Catalyst. Eur. J. Org. Chem. 2019, 486.

12. Frederick J. Seidl‡, Chang Min^‡, Jovan A. Lopez, Noah Z. Burns*. Catalytic Regio‑ and Enantioselective Haloazidation of Allylic Alcohols. J. Am. Chem. Soc. 2018, 140, 15646.

11. Chang Min, Daniel Seidel*. Asymmetric Brønsted Acid Catalysis with Chiral Carboxylic Acids. Chem. Soc. Rev. 2017, 46, 5889−5902.

10. Chang Min^‡, Yingfu Lin^‡, Daniel Seidel*. Catalytic Enantioselective Synthesis of Mariline A and Related Isoindolinones via a Biomimetic Approach. Angew. Chem. Int. Ed. 2017, 56, 15353.

9. Chang Min, Daniel Seidel*.  Stereochemically Rich Polycyclic Amines fom the Kinetic Resolution of Indolines via Intramolecular Povarov Reactions. Chem. Eur. J. 2016, 22, 10817−10820.

8. Chang Min, Chih-Tsung Lin, Daniel Seidel*. Catalytic Enantioselective Intramolecular Aza‑Diels–Alder Reactions. Angew. Chem. Int. Ed. 2015, 54, 6608–6612.

7. Chang Min, Abbas Sanchawala, Daniel Seidel*. Dual C–H Functionalization of N‑Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach. Org. Lett. 2014, 16, 2756–2759.

6. Chang Min^‡, Nisha Mittal^‡, Diana X. Sun, Daniel Seidel*. Conjugate‑Base‑Stabilized Brønsted Acids as Asymmetric Catalysts: Enantioselective Povarov Reactions with Secondary Aromatic Amines. Angew. Chem. Int. Ed. 2013, 52, 14084–14088.

5. Xin Han, Xiangfei Wu, Chang Min, Hai-Bing Zhou, Chune Dong*. An expedient approach to highly enantioenriched cyclic nitrones mediated by robust and recoverable C3‑symmetric cinchonine‑squaramide catalysts. RSC Adv. 2012, 2, 7501–7505.

4. Chang Min, Nisha Mittal, Chandra Kanta De, Daniel Seidel*. A Dual‑Catalysis Approach to the Kinetic Resolution of 1,2‑diaryl‑1,2‑diaminoethanes. Chem. Commun. 2012, 48, 10853–10855.

3. Chang Min, Xin Han, Zongquan Liao, Xiangfei Wu, Hai-Bing Zhou, Chune Dong*. C3‑Symmetrical Cinchonine‑Squaramide as New Highly Efficient, and Recyclable Organocatalyst for Enantioselective Michael Addition. Adv. Synth. Catal. 2011, 353, 2715–2720.

2. Xiang-Fei Wu, Chang Min, Enkhtsetseg Nyamzundui, Hai-Bing Zhou, Chune Dong*. A novel C-3-symmetric prolinol-squaramide catalyst for the asymmetric reduction of ketones by borane. Tetrahedron: Asymmetry 2011, 22, 1640–1643.

1. Ze Dong, Xiaoqing Jin, Pengcheng Wang, Chang Min, Jin Zhang, Zhe Chen, Hai-Bing Zhou, Chune Dong*. Novel bifunctional chiral squaramide-amine catalysts for highly enantioselective addition of mono- and diketones to nitroalkenes. Arkivoc 2011, 367–380.